Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. [electronic resource]
Producer: 20121214Description: 534-41 p. digitalISSN:- 1555-8576
- Animals
- Antineoplastic Agents -- administration & dosage
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Benzenesulfonates -- administration & dosage
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Interleukin-6 -- metabolism
- Janus Kinase 2 -- metabolism
- Lysophospholipids -- metabolism
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Mitogen-Activated Protein Kinases -- metabolism
- Neuroblastoma -- drug therapy
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Phosphorylation -- drug effects
- Pyridines -- administration & dosage
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Sorafenib
- Sphingosine -- analogs & derivatives
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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