Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.

Yang, Fan

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. [electronic resource] - Cancer biology & therapy May 2012 - 534-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1555-8576

10.4161/cbt.19603 doi


Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Apoptosis Regulatory Proteins--genetics
Benzenesulfonates--administration & dosage
Cell Line, Tumor
Cell Proliferation--drug effects
Female
Gene Expression Regulation, Neoplastic--drug effects
Humans
Interleukin-6--metabolism
Janus Kinase 2--metabolism
Lysophospholipids--metabolism
Mice
Mice, Inbred NOD
Mice, SCID
Mitogen-Activated Protein Kinases--metabolism
Neuroblastoma--drug therapy
Niacinamide--analogs & derivatives
Phenylurea Compounds
Phosphorylation--drug effects
Pyridines--administration & dosage
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Sorafenib
Sphingosine--analogs & derivatives
Xenograft Model Antitumor Assays