DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress. [electronic resource]
Producer: 20120904Description: e1002557 p. digitalISSN:- 1553-7404
- Animals
- Bleomycin -- pharmacology
- Cell Cycle Proteins -- genetics
- Cells, Cultured
- DNA Breaks, Double-Stranded
- DNA Damage -- drug effects
- DNA-Binding Proteins
- Gene Expression Regulation
- Gene Knockdown Techniques
- Humans
- Mice
- Mice, Mutant Strains
- NAD -- metabolism
- Nijmegen Breakage Syndrome -- genetics
- Nuclear Proteins -- genetics
- Oxidative Stress -- drug effects
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- genetics
- Reactive Oxygen Species -- metabolism
- Transcriptional Activation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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