DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.

Krenzlin, Harald

DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress. [electronic resource] - PLoS genetics 2012 - e1002557 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1553-7404

10.1371/journal.pgen.1002557 doi


Animals
Bleomycin--pharmacology
Cell Cycle Proteins--genetics
Cells, Cultured
DNA Breaks, Double-Stranded
DNA Damage--drug effects
DNA-Binding Proteins
Gene Expression Regulation
Gene Knockdown Techniques
Humans
Mice
Mice, Mutant Strains
NAD--metabolism
Nijmegen Breakage Syndrome--genetics
Nuclear Proteins--genetics
Oxidative Stress--drug effects
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases--genetics
Reactive Oxygen Species--metabolism
Transcriptional Activation