Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.
Stevenson, Ralph J
Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy. [electronic resource] - Journal of medicinal chemistry Mar 2012 - 2780-802 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm201717y doi
Animals
Antineoplastic Agents, Alkylating--chemical synthesis
Cell Hypoxia
Cell Line, Tumor
Combined Modality Therapy
Drug Screening Assays, Antitumor
Humans
Indoles--chemical synthesis
Male
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms--drug therapy
Neoplasms, Experimental--drug therapy
Nitro Compounds--chemical synthesis
Prodrugs--chemical synthesis
Structure-Activity Relationship
Sulfonic Acids--chemistry
Transplantation, Heterologous
Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy. [electronic resource] - Journal of medicinal chemistry Mar 2012 - 2780-802 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm201717y doi
Animals
Antineoplastic Agents, Alkylating--chemical synthesis
Cell Hypoxia
Cell Line, Tumor
Combined Modality Therapy
Drug Screening Assays, Antitumor
Humans
Indoles--chemical synthesis
Male
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms--drug therapy
Neoplasms, Experimental--drug therapy
Nitro Compounds--chemical synthesis
Prodrugs--chemical synthesis
Structure-Activity Relationship
Sulfonic Acids--chemistry
Transplantation, Heterologous