A novel diabetes mellitus mouse model, MAFA-deficient and beta cell-specific MAFK-overexpressing hybrid transgenic mice, developed severe diabetic nephropathy and improved with TCV-116 (candesartan cilexetil) treatment. [electronic resource]
Producer: 20120522Description: 49-57 p. digitalISSN:- 1881-7122
- 8-Hydroxy-2'-Deoxyguanosine
- Angiotensin II Type 1 Receptor Blockers -- therapeutic use
- Animals
- Benzimidazoles -- therapeutic use
- Biphenyl Compounds -- therapeutic use
- Deoxyguanosine -- analogs & derivatives
- Diabetes Mellitus, Experimental -- genetics
- Diabetes Mellitus, Type 2 -- physiopathology
- Diabetic Nephropathies -- drug therapy
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Humans
- Kidney -- pathology
- Maf Transcription Factors, Large -- genetics
- MafK Transcription Factor -- genetics
- Male
- Mice
- Mice, Transgenic
- Nephrectomy
- Tetrazoles -- therapeutic use
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Publication Type: Journal Article
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