A novel diabetes mellitus mouse model, MAFA-deficient and beta cell-specific MAFK-overexpressing hybrid transgenic mice, developed severe diabetic nephropathy and improved with TCV-116 (candesartan cilexetil) treatment.
Fujita, Akiko
A novel diabetes mellitus mouse model, MAFA-deficient and beta cell-specific MAFK-overexpressing hybrid transgenic mice, developed severe diabetic nephropathy and improved with TCV-116 (candesartan cilexetil) treatment. [electronic resource] - Experimental animals 2012 - 49-57 p. digital
Publication Type: Journal Article
1881-7122
10.1538/expanim.61.49 doi
8-Hydroxy-2'-Deoxyguanosine
Angiotensin II Type 1 Receptor Blockers--therapeutic use
Animals
Benzimidazoles--therapeutic use
Biphenyl Compounds--therapeutic use
Deoxyguanosine--analogs & derivatives
Diabetes Mellitus, Experimental--genetics
Diabetes Mellitus, Type 2--physiopathology
Diabetic Nephropathies--drug therapy
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Humans
Kidney--pathology
Maf Transcription Factors, Large--genetics
MafK Transcription Factor--genetics
Male
Mice
Mice, Transgenic
Nephrectomy
Tetrazoles--therapeutic use
A novel diabetes mellitus mouse model, MAFA-deficient and beta cell-specific MAFK-overexpressing hybrid transgenic mice, developed severe diabetic nephropathy and improved with TCV-116 (candesartan cilexetil) treatment. [electronic resource] - Experimental animals 2012 - 49-57 p. digital
Publication Type: Journal Article
1881-7122
10.1538/expanim.61.49 doi
8-Hydroxy-2'-Deoxyguanosine
Angiotensin II Type 1 Receptor Blockers--therapeutic use
Animals
Benzimidazoles--therapeutic use
Biphenyl Compounds--therapeutic use
Deoxyguanosine--analogs & derivatives
Diabetes Mellitus, Experimental--genetics
Diabetes Mellitus, Type 2--physiopathology
Diabetic Nephropathies--drug therapy
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Humans
Kidney--pathology
Maf Transcription Factors, Large--genetics
MafK Transcription Factor--genetics
Male
Mice
Mice, Transgenic
Nephrectomy
Tetrazoles--therapeutic use