The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. [electronic resource]
Producer: 20120523Description: 1-10 p. digitalISSN:- 1872-7786
- Animals
- Aryl Hydrocarbon Hydroxylases -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cytochrome P-450 CYP1B1
- Cytochrome P-450 CYP3A -- metabolism
- Dose-Response Relationship, Drug
- Equilenin -- analogs & derivatives
- Female
- Half-Life
- Inhibitory Concentration 50
- Kinetics
- Magnetic Resonance Spectroscopy
- Microsomes, Liver
- Naphthalenes -- chemistry
- Oxidation-Reduction
- Piperidines -- chemistry
- Quinones -- chemistry
- Rats
- Rats, Sprague-Dawley
- Selective Estrogen Receptor Modulators -- chemistry
- Tandem Mass Spectrometry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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