The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.

Gherezghiher, Teshome B

The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. [electronic resource] - Chemico-biological interactions Mar 2012 - 1-10 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1872-7786

10.1016/j.cbi.2012.01.004 doi


Animals
Aryl Hydrocarbon Hydroxylases--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Cytochrome P-450 CYP1B1
Cytochrome P-450 CYP3A--metabolism
Dose-Response Relationship, Drug
Equilenin--analogs & derivatives
Female
Half-Life
Inhibitory Concentration 50
Kinetics
Magnetic Resonance Spectroscopy
Microsomes, Liver
Naphthalenes--chemistry
Oxidation-Reduction
Piperidines--chemistry
Quinones--chemistry
Rats
Rats, Sprague-Dawley
Selective Estrogen Receptor Modulators--chemistry
Tandem Mass Spectrometry