Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. [electronic resource]
Producer: 20120612Description: 3836-43 p. digitalISSN:- 1528-0020
- ADAM Proteins -- chemistry
- ADAMTS13 Protein
- Adult
- Aged
- Animals
- Antibody Specificity
- Autoantibodies -- immunology
- Binding Sites, Antibody -- immunology
- COS Cells
- Chlorocebus aethiops
- Female
- Genetic Variation
- Humans
- Immunoglobulin G -- immunology
- Immunotherapy -- methods
- Male
- Middle Aged
- Mutagenesis, Site-Directed
- Protein Structure, Tertiary
- Purpura, Thrombotic Thrombocytopenic -- genetics
- Recombinant Proteins -- chemistry
- Young Adult
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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