Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.

Jian, Cui

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura. [electronic resource] - Blood Apr 2012 - 3836-43 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0020

10.1182/blood-2011-12-399501 doi


ADAM Proteins--chemistry
ADAMTS13 Protein
Adult
Aged
Animals
Antibody Specificity
Autoantibodies--immunology
Binding Sites, Antibody--immunology
COS Cells
Chlorocebus aethiops
Female
Genetic Variation
Humans
Immunoglobulin G--immunology
Immunotherapy--methods
Male
Middle Aged
Mutagenesis, Site-Directed
Protein Structure, Tertiary
Purpura, Thrombotic Thrombocytopenic--genetics
Recombinant Proteins--chemistry
Young Adult