Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. [electronic resource]
Producer: 20120402Description: 400-7 p. digitalISSN:- 1468-2060
- Animals
- Arthritis, Experimental -- complications
- Biphenyl Compounds -- pharmacology
- Bone and Bones -- metabolism
- Cartilage, Articular -- metabolism
- Cell Differentiation -- genetics
- Chondrocytes -- pathology
- Drug Evaluation, Preclinical -- methods
- Hedgehog Proteins -- antagonists & inhibitors
- Hypertrophy
- Male
- Mice
- Mice, Inbred C57BL
- Microscopy, Fluorescence
- Osteoblasts -- pathology
- Osteophyte -- etiology
- Periosteum -- pathology
- Receptors, G-Protein-Coupled -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Smoothened Receptor
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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