Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis.

Ruiz-Heiland, Gisela

Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. [electronic resource] - Annals of the rheumatic diseases Mar 2012 - 400-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1468-2060

10.1136/ard.2010.148262 doi


Animals
Arthritis, Experimental--complications
Biphenyl Compounds--pharmacology
Bone and Bones--metabolism
Cartilage, Articular--metabolism
Cell Differentiation--genetics
Chondrocytes--pathology
Drug Evaluation, Preclinical--methods
Hedgehog Proteins--antagonists & inhibitors
Hypertrophy
Male
Mice
Mice, Inbred C57BL
Microscopy, Fluorescence
Osteoblasts--pathology
Osteophyte--etiology
Periosteum--pathology
Receptors, G-Protein-Coupled--antagonists & inhibitors
Signal Transduction--drug effects
Smoothened Receptor
Up-Regulation--drug effects