A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. [electronic resource]
Producer: 20121010Description: 1097-113 p. digitalISSN:- 1476-5381
- Animals
- Blotting, Western
- Brain -- drug effects
- Cell Culture Techniques
- Cell Line, Tumor
- Cell Survival -- drug effects
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microscopy, Fluorescence
- Motor Activity -- drug effects
- Oxidative Stress -- drug effects
- Parkinsonian Disorders -- drug therapy
- Proline -- analogs & derivatives
- Prolyl Oligopeptidases
- Reverse Transcriptase Polymerase Chain Reaction
- Serine Endopeptidases -- metabolism
- Serine Proteinase Inhibitors -- pharmacology
- Transfection
- alpha-Synuclein -- genetics
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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