A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.
Myöhänen, T T
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. [electronic resource] - British journal of pharmacology Jun 2012 - 1097-113 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5381
10.1111/j.1476-5381.2012.01846.x doi
Animals
Blotting, Western
Brain--drug effects
Cell Culture Techniques
Cell Line, Tumor
Cell Survival--drug effects
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Fluorescence
Motor Activity--drug effects
Oxidative Stress--drug effects
Parkinsonian Disorders--drug therapy
Proline--analogs & derivatives
Prolyl Oligopeptidases
Reverse Transcriptase Polymerase Chain Reaction
Serine Endopeptidases--metabolism
Serine Proteinase Inhibitors--pharmacology
Transfection
alpha-Synuclein--genetics
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. [electronic resource] - British journal of pharmacology Jun 2012 - 1097-113 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5381
10.1111/j.1476-5381.2012.01846.x doi
Animals
Blotting, Western
Brain--drug effects
Cell Culture Techniques
Cell Line, Tumor
Cell Survival--drug effects
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Fluorescence
Motor Activity--drug effects
Oxidative Stress--drug effects
Parkinsonian Disorders--drug therapy
Proline--analogs & derivatives
Prolyl Oligopeptidases
Reverse Transcriptase Polymerase Chain Reaction
Serine Endopeptidases--metabolism
Serine Proteinase Inhibitors--pharmacology
Transfection
alpha-Synuclein--genetics