Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. [electronic resource]
Producer: 20120618Description: 452-63 p. digitalISSN:- 1538-8514
- Animals
- Apoptosis -- drug effects
- Benzenesulfonates -- pharmacology
- Benzimidazoles -- chemistry
- Blotting, Western
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm -- drug effects
- Humans
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Mice, Nude
- Molecular Structure
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Protein Kinase Inhibitors -- chemistry
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 -- genetics
- Pyridines -- pharmacology
- Quinolones -- chemistry
- RNA Interference
- STAT3 Transcription Factor -- genetics
- Sorafenib
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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