Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3.

Tai, Wei-Tien

Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. [electronic resource] - Molecular cancer therapeutics Feb 2012 - 452-63 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-8514

10.1158/1535-7163.MCT-11-0412 doi


Animals
Apoptosis--drug effects
Benzenesulfonates--pharmacology
Benzimidazoles--chemistry
Blotting, Western
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm--drug effects
Humans
Liver Neoplasms--drug therapy
Male
Mice
Mice, Nude
Molecular Structure
Niacinamide--analogs & derivatives
Phenylurea Compounds
Protein Kinase Inhibitors--chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 6--genetics
Pyridines--pharmacology
Quinolones--chemistry
RNA Interference
STAT3 Transcription Factor--genetics
Sorafenib
Tumor Burden--drug effects
Xenograft Model Antitumor Assays