Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. [electronic resource]
Producer: 20120705Description: 910-7 p. digitalISSN:- 1476-5551
- Acetylation
- Animals
- Antigens, CD34 -- metabolism
- Apoptosis -- drug effects
- Cell Line, Tumor
- Flow Cytometry
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, p53
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Imidazoles -- pharmacology
- Leukemia, Myeloid, Acute -- genetics
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Microscopy, Electron, Transmission
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Valproic Acid -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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