Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
McCormack, E
Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. [electronic resource] - Leukemia May 2012 - 910-7 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5551
10.1038/leu.2011.315 doi
Acetylation
Animals
Antigens, CD34--metabolism
Apoptosis--drug effects
Cell Line, Tumor
Flow Cytometry
Gene Expression Regulation, Neoplastic--drug effects
Genes, p53
Histone Deacetylase Inhibitors--pharmacology
Humans
Imidazoles--pharmacology
Leukemia, Myeloid, Acute--genetics
Mice
Mice, Inbred NOD
Mice, SCID
Microscopy, Electron, Transmission
Piperazines--pharmacology
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Valproic Acid--pharmacology
Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. [electronic resource] - Leukemia May 2012 - 910-7 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5551
10.1038/leu.2011.315 doi
Acetylation
Animals
Antigens, CD34--metabolism
Apoptosis--drug effects
Cell Line, Tumor
Flow Cytometry
Gene Expression Regulation, Neoplastic--drug effects
Genes, p53
Histone Deacetylase Inhibitors--pharmacology
Humans
Imidazoles--pharmacology
Leukemia, Myeloid, Acute--genetics
Mice
Mice, Inbred NOD
Mice, SCID
Microscopy, Electron, Transmission
Piperazines--pharmacology
Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors
Valproic Acid--pharmacology