Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. [electronic resource]
Producer: 20120404Description: 7155-67 p. digitalISSN:- 1538-7445
- Animals
- Apoptosis -- drug effects
- Brain Neoplasms -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- DNA Damage
- DNA Repair
- Glioblastoma -- drug therapy
- Humans
- Mesenchymal Stem Cells -- drug effects
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Microarray Analysis -- methods
- Neoplasm Invasiveness
- Neoplastic Stem Cells -- drug effects
- Neovascularization, Pathologic -- drug therapy
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrazoles -- pharmacology
- Pyrroles -- pharmacology
- Radiation Tolerance -- drug effects
- Radiation-Sensitizing Agents -- pharmacology
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Smad2 Protein -- antagonists & inhibitors
- Transforming Growth Factor beta -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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