Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.
Zhang, Mengxian
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. [electronic resource] - Cancer research Dec 2011 - 7155-67 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-11-1212 doi
Animals
Apoptosis--drug effects
Brain Neoplasms--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
DNA Damage
DNA Repair
Glioblastoma--drug therapy
Humans
Mesenchymal Stem Cells--drug effects
Mice
Mice, Inbred BALB C
Mice, SCID
Microarray Analysis--methods
Neoplasm Invasiveness
Neoplastic Stem Cells--drug effects
Neovascularization, Pathologic--drug therapy
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyrazoles--pharmacology
Pyrroles--pharmacology
Radiation Tolerance--drug effects
Radiation-Sensitizing Agents--pharmacology
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta--antagonists & inhibitors
Signal Transduction--drug effects
Smad2 Protein--antagonists & inhibitors
Transforming Growth Factor beta--antagonists & inhibitors
Xenograft Model Antitumor Assays
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. [electronic resource] - Cancer research Dec 2011 - 7155-67 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-11-1212 doi
Animals
Apoptosis--drug effects
Brain Neoplasms--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
DNA Damage
DNA Repair
Glioblastoma--drug therapy
Humans
Mesenchymal Stem Cells--drug effects
Mice
Mice, Inbred BALB C
Mice, SCID
Microarray Analysis--methods
Neoplasm Invasiveness
Neoplastic Stem Cells--drug effects
Neovascularization, Pathologic--drug therapy
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyrazoles--pharmacology
Pyrroles--pharmacology
Radiation Tolerance--drug effects
Radiation-Sensitizing Agents--pharmacology
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta--antagonists & inhibitors
Signal Transduction--drug effects
Smad2 Protein--antagonists & inhibitors
Transforming Growth Factor beta--antagonists & inhibitors
Xenograft Model Antitumor Assays