A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells. [electronic resource]
Producer: 20130403Description: 1887-98 p. digitalISSN:- 1573-0646
- Animals
- Antineoplastic Agents, Hormonal -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- genetics
- Autophagy -- drug effects
- Beclin-1
- Breast Neoplasms -- drug therapy
- Caspases -- genetics
- Cell Cycle Checkpoints -- drug effects
- Cell Death -- drug effects
- Cell Division -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm
- Female
- G2 Phase -- drug effects
- Histone Deacetylase Inhibitors -- pharmacology
- Histone Deacetylases -- genetics
- Humans
- MCF-7 Cells
- Membrane Proteins -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phenyl Ethers -- pharmacology
- Pimelic Acids -- pharmacology
- Proliferating Cell Nuclear Antigen -- genetics
- Tamoxifen -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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