A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells.

Park, Ji Hye

A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells. [electronic resource] - Investigational new drugs Oct 2012 - 1887-98 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1573-0646

10.1007/s10637-011-9752-z doi


Animals
Antineoplastic Agents, Hormonal--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--genetics
Autophagy--drug effects
Beclin-1
Breast Neoplasms--drug therapy
Caspases--genetics
Cell Cycle Checkpoints--drug effects
Cell Death--drug effects
Cell Division--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Resistance, Neoplasm
Female
G2 Phase--drug effects
Histone Deacetylase Inhibitors--pharmacology
Histone Deacetylases--genetics
Humans
MCF-7 Cells
Membrane Proteins--genetics
Mice
Mice, Inbred BALB C
Mice, Nude
Phenyl Ethers--pharmacology
Pimelic Acids--pharmacology
Proliferating Cell Nuclear Antigen--genetics
Tamoxifen--pharmacology
Xenograft Model Antitumor Assays