The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions. [electronic resource]
Producer: 20120821Description: R81 p. digitalISSN:- 1465-542X
- 9,10-Dimethyl-1,2-benzanthracene -- toxicity
- Alleles
- Animals
- Breast Neoplasms -- genetics
- CD4-Positive T-Lymphocytes -- immunology
- CD8 Antigens -- metabolism
- Cytokines -- metabolism
- Epithelial Cells -- metabolism
- Female
- Genetic Loci
- Genetic Predisposition to Disease
- Homeostasis
- L-Selectin -- metabolism
- Mammary Neoplasms, Experimental -- chemically induced
- Methylnitrosourea -- adverse effects
- NK Cell Lectin-Like Receptor Subfamily B -- metabolism
- Rats
- Rats, Inbred WKY
- Receptors, Antigen, T-Cell -- metabolism
- T-Lymphocytes -- immunology
- Th1 Cells -- immunology
- Th2 Cells -- immunology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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