The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.

Smits, Bart M G

The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions. [electronic resource] - Breast cancer research : BCR Aug 2011 - R81 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

1465-542X

10.1186/bcr2933 doi


9,10-Dimethyl-1,2-benzanthracene--toxicity
Alleles
Animals
Breast Neoplasms--genetics
CD4-Positive T-Lymphocytes--immunology
CD8 Antigens--metabolism
Cytokines--metabolism
Epithelial Cells--metabolism
Female
Genetic Loci
Genetic Predisposition to Disease
Homeostasis
L-Selectin--metabolism
Mammary Neoplasms, Experimental--chemically induced
Methylnitrosourea--adverse effects
NK Cell Lectin-Like Receptor Subfamily B--metabolism
Rats
Rats, Inbred WKY
Receptors, Antigen, T-Cell--metabolism
T-Lymphocytes--immunology
Th1 Cells--immunology
Th2 Cells--immunology