All-trans retinoic acid induces cellular senescence by up-regulating levels of p16 and p21 via promoter hypomethylation. [electronic resource]
Producer: 20111121Description: 500-5 p. digitalISSN:- 1090-2104
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16 -- genetics
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- DNA (Cytosine-5-)-Methyltransferases -- antagonists & inhibitors
- DNA Methylation -- drug effects
- Hep G2 Cells
- Humans
- Promoter Regions, Genetic -- drug effects
- Proto-Oncogene Protein c-ets-1 -- metabolism
- Proto-Oncogene Protein c-ets-2 -- metabolism
- Receptors, Retinoic Acid -- genetics
- Tretinoin -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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