All-trans retinoic acid induces cellular senescence by up-regulating levels of p16 and p21 via promoter hypomethylation.

Lim, Joo Song

All-trans retinoic acid induces cellular senescence by up-regulating levels of p16 and p21 via promoter hypomethylation. [electronic resource] - Biochemical and biophysical research communications Sep 2011 - 500-5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1090-2104

10.1016/j.bbrc.2011.07.130 doi


Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16--genetics
Cyclin-Dependent Kinase Inhibitor p21--genetics
DNA (Cytosine-5-)-Methyltransferases--antagonists & inhibitors
DNA Methylation--drug effects
Hep G2 Cells
Humans
Promoter Regions, Genetic--drug effects
Proto-Oncogene Protein c-ets-1--metabolism
Proto-Oncogene Protein c-ets-2--metabolism
Receptors, Retinoic Acid--genetics
Tretinoin--pharmacology