Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). [electronic resource]
Producer: 20120223Description: 79 p. digitalISSN:- 1742-2094
- Amyloid beta-Peptides -- pharmacology
- Animals
- Cell Line
- Cytokines -- metabolism
- Female
- Interleukin-1beta -- metabolism
- Ligands
- Lipopolysaccharides -- pharmacology
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microglia -- cytology
- Mitogen-Activated Protein Kinase 14 -- antagonists & inhibitors
- Peptide Fragments -- pharmacology
- Pyridazines -- metabolism
- Pyrimidines -- metabolism
- Rats
- Rats, Sprague-Dawley
- Signal Transduction -- physiology
- Toll-Like Receptors -- agonists
- Tumor Necrosis Factor-alpha -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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