PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. [electronic resource]
Producer: 20110909Description: 564-74 p. digitalISSN:- 1096-9896
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carcinoma, Non-Small-Cell Lung -- genetics
- Cisplatin -- pharmacology
- DNA Damage
- DNA, Neoplasm -- genetics
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- pharmacology
- Gene Silencing
- Humans
- Lung Neoplasms -- genetics
- Mitochondria -- pathology
- Poly(ADP-ribose) Polymerase Inhibitors
- RNA, Small Interfering -- genetics
- Tumor Cells, Cultured
- Ubiquitin-Protein Ligases -- deficiency
- bcl-2 Homologous Antagonist-Killer Protein -- physiology
- bcl-2-Associated X Protein -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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