PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer.

Paul, Ian

PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. [electronic resource] - The Journal of pathology Aug 2011 - 564-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-9896

10.1002/path.2925 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Carcinoma, Non-Small-Cell Lung--genetics
Cisplatin--pharmacology
DNA Damage
DNA, Neoplasm--genetics
Drug Resistance, Neoplasm
Enzyme Inhibitors--pharmacology
Gene Silencing
Humans
Lung Neoplasms--genetics
Mitochondria--pathology
Poly(ADP-ribose) Polymerase Inhibitors
RNA, Small Interfering--genetics
Tumor Cells, Cultured
Ubiquitin-Protein Ligases--deficiency
bcl-2 Homologous Antagonist-Killer Protein--physiology
bcl-2-Associated X Protein--physiology