Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. [electronic resource]
Producer: 20120227Description: 1609-19 p. digitalISSN:- 1521-009X
- Administration, Oral
- Adult
- Animals
- Biological Availability
- Biotransformation
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacokinetics
- Caco-2 Cells
- Cross-Over Studies
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Dogs
- Drug Evaluation, Preclinical
- Female
- Glucuronosyltransferase -- metabolism
- HEK293 Cells
- Hepatocytes -- drug effects
- Humans
- Intestinal Absorption
- Male
- Microsomes, Liver -- enzymology
- Middle Aged
- Protein Binding
- Rats
- Rats, Sprague-Dawley
- Sodium-Glucose Transport Proteins -- antagonists & inhibitors
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial
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