Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. [electronic resource]
Producer: 20111014Description: 516-25 p. digitalISSN:- 1476-5586
- Animals
- Animals, Newborn
- Antineoplastic Agents -- pharmacology
- Bone Neoplasms -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Epithelial-Mesenchymal Transition -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Immunohistochemistry
- Integrin alphaV -- metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplastic Stem Cells -- drug effects
- Neovascularization, Pathologic -- prevention & control
- Osteoclasts -- drug effects
- Prostatic Neoplasms -- drug therapy
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Burden -- drug effects
- Tumor Microenvironment -- drug effects
- Twist-Related Protein 1 -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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