Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer.
van der Horst, Geertje
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. [electronic resource] - Neoplasia (New York, N.Y.) Jun 2011 - 516-25 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5586
10.1593/neo.11122 doi
Animals
Animals, Newborn
Antineoplastic Agents--pharmacology
Bone Neoplasms--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Epithelial-Mesenchymal Transition--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Humans
Immunohistochemistry
Integrin alphaV--metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplastic Stem Cells--drug effects
Neovascularization, Pathologic--prevention & control
Osteoclasts--drug effects
Prostatic Neoplasms--drug therapy
Reverse Transcriptase Polymerase Chain Reaction
Tumor Burden--drug effects
Tumor Microenvironment--drug effects
Twist-Related Protein 1--genetics
Xenograft Model Antitumor Assays
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. [electronic resource] - Neoplasia (New York, N.Y.) Jun 2011 - 516-25 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5586
10.1593/neo.11122 doi
Animals
Animals, Newborn
Antineoplastic Agents--pharmacology
Bone Neoplasms--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Epithelial-Mesenchymal Transition--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Humans
Immunohistochemistry
Integrin alphaV--metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplastic Stem Cells--drug effects
Neovascularization, Pathologic--prevention & control
Osteoclasts--drug effects
Prostatic Neoplasms--drug therapy
Reverse Transcriptase Polymerase Chain Reaction
Tumor Burden--drug effects
Tumor Microenvironment--drug effects
Twist-Related Protein 1--genetics
Xenograft Model Antitumor Assays