The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. [electronic resource]
Producer: 20111201Description: 707-15 p. digitalISSN:- 1872-8278
- Adenosine Triphosphate -- biosynthesis
- Animals
- Antioxidants -- pharmacology
- Cells, Cultured
- Chaperonin 60 -- metabolism
- Chromans -- pharmacology
- Citrate (si)-Synthase -- metabolism
- Cytochromes b5 -- metabolism
- Dopaminergic Neurons -- drug effects
- Electron Transport Complex I -- metabolism
- Electron Transport Complex II -- metabolism
- Electron Transport Complex IV -- metabolism
- Enzyme Assays
- Humans
- Intracellular Signaling Peptides and Proteins -- deficiency
- Mice
- Mice, Knockout
- Mitochondria -- enzymology
- Mitochondrial Proteins -- metabolism
- Oncogene Proteins -- deficiency
- Oxidative Stress
- Oxygen Consumption
- Parkinsonian Disorders -- drug therapy
- Protein Deglycase DJ-1
- Protein Kinases -- deficiency
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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