The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells.

Shim, Jung Hee

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. [electronic resource] - Mitochondrion Sep 2011 - 707-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-8278

10.1016/j.mito.2011.05.013 doi


Adenosine Triphosphate--biosynthesis
Animals
Antioxidants--pharmacology
Cells, Cultured
Chaperonin 60--metabolism
Chromans--pharmacology
Citrate (si)-Synthase--metabolism
Cytochromes b5--metabolism
Dopaminergic Neurons--drug effects
Electron Transport Complex I--metabolism
Electron Transport Complex II--metabolism
Electron Transport Complex IV--metabolism
Enzyme Assays
Humans
Intracellular Signaling Peptides and Proteins--deficiency
Mice
Mice, Knockout
Mitochondria--enzymology
Mitochondrial Proteins--metabolism
Oncogene Proteins--deficiency
Oxidative Stress
Oxygen Consumption
Parkinsonian Disorders--drug therapy
Protein Deglycase DJ-1
Protein Kinases--deficiency