A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. [electronic resource]
Producer: 20111114Description: 925-35 p. digitalISSN:- 1557-3125
- Brain Neoplasms -- drug therapy
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Line, Tumor
- Cell Proliferation
- Cells, Cultured
- Cisplatin -- therapeutic use
- Class Ib Phosphatidylinositol 3-Kinase -- genetics
- Combined Modality Therapy
- Down-Regulation -- genetics
- Drug Resistance, Neoplasm -- genetics
- Gene Expression Regulation, Neoplastic
- Humans
- Medulloblastoma -- drug therapy
- Phosphoinositide-3 Kinase Inhibitors
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- RNA Interference
- RNA, Small Interfering -- genetics
- Thiazolidinediones -- pharmacology
- Polo-Like Kinase 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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