A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

Guerreiro, Ana S

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. [electronic resource] - Molecular cancer research : MCR Jul 2011 - 925-35 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1557-3125

10.1158/1541-7786.MCR-10-0200 doi


Brain Neoplasms--drug therapy
Cell Cycle Proteins--antagonists & inhibitors
Cell Line, Tumor
Cell Proliferation
Cells, Cultured
Cisplatin--therapeutic use
Class Ib Phosphatidylinositol 3-Kinase--genetics
Combined Modality Therapy
Down-Regulation--genetics
Drug Resistance, Neoplasm--genetics
Gene Expression Regulation, Neoplastic
Humans
Medulloblastoma--drug therapy
Phosphoinositide-3 Kinase Inhibitors
Protein Serine-Threonine Kinases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--antagonists & inhibitors
RNA Interference
RNA, Small Interfering--genetics
Thiazolidinediones--pharmacology
Polo-Like Kinase 1