Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1. [electronic resource]
Producer: 20111003Description: 5265-75 p. digitalISSN:- 1538-7445
- Adenocarcinoma -- blood supply
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- CDC2 Protein Kinase -- antagonists & inhibitors
- Camptothecin -- analogs & derivatives
- Cell Hypoxia -- drug effects
- Cell Line, Tumor -- drug effects
- Colonic Neoplasms -- blood supply
- Drug Synergism
- Fluorouracil -- pharmacology
- Gene Expression Regulation, Neoplastic -- drug effects
- Glycogen Synthase Kinase 3 -- antagonists & inhibitors
- Glycogen Synthase Kinase 3 beta
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors
- Inhibitor of Apoptosis Proteins -- physiology
- Irinotecan
- Mice
- Mice, Nude
- Neoplasm Proteins -- antagonists & inhibitors
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-myb -- physiology
- Pyrimidines -- pharmacology
- RNA, Small Interfering -- pharmacology
- Recombinant Proteins -- pharmacology
- TNF-Related Apoptosis-Inducing Ligand -- pharmacology
- Thiazoles -- pharmacology
- Tumor Suppressor Protein p53 -- physiology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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