Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.
Mayes, Patrick A
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1. [electronic resource] - Cancer research Aug 2011 - 5265-75 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-11-1383 doi
Adenocarcinoma--blood supply
Angiogenesis Inhibitors--pharmacology
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
CDC2 Protein Kinase--antagonists & inhibitors
Camptothecin--analogs & derivatives
Cell Hypoxia--drug effects
Cell Line, Tumor--drug effects
Colonic Neoplasms--blood supply
Drug Synergism
Fluorouracil--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Glycogen Synthase Kinase 3--antagonists & inhibitors
Glycogen Synthase Kinase 3 beta
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--antagonists & inhibitors
Inhibitor of Apoptosis Proteins--physiology
Irinotecan
Mice
Mice, Nude
Neoplasm Proteins--antagonists & inhibitors
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-myb--physiology
Pyrimidines--pharmacology
RNA, Small Interfering--pharmacology
Recombinant Proteins--pharmacology
TNF-Related Apoptosis-Inducing Ligand--pharmacology
Thiazoles--pharmacology
Tumor Suppressor Protein p53--physiology
Xenograft Model Antitumor Assays
Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1. [electronic resource] - Cancer research Aug 2011 - 5265-75 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1538-7445
10.1158/0008-5472.CAN-11-1383 doi
Adenocarcinoma--blood supply
Angiogenesis Inhibitors--pharmacology
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
CDC2 Protein Kinase--antagonists & inhibitors
Camptothecin--analogs & derivatives
Cell Hypoxia--drug effects
Cell Line, Tumor--drug effects
Colonic Neoplasms--blood supply
Drug Synergism
Fluorouracil--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Glycogen Synthase Kinase 3--antagonists & inhibitors
Glycogen Synthase Kinase 3 beta
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--antagonists & inhibitors
Inhibitor of Apoptosis Proteins--physiology
Irinotecan
Mice
Mice, Nude
Neoplasm Proteins--antagonists & inhibitors
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-myb--physiology
Pyrimidines--pharmacology
RNA, Small Interfering--pharmacology
Recombinant Proteins--pharmacology
TNF-Related Apoptosis-Inducing Ligand--pharmacology
Thiazoles--pharmacology
Tumor Suppressor Protein p53--physiology
Xenograft Model Antitumor Assays