Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo. [electronic resource]
Producer: 20120105Description: 107-16 p. digitalISSN:- 1096-0961
- Administration, Oral
- Anemia -- drug therapy
- Animals
- Biological Products -- administration & dosage
- Cells, Cultured
- Drug Design
- Erythroid Precursor Cells -- cytology
- Fetal Hemoglobin -- biosynthesis
- Gene Expression
- Humans
- Injections, Intravenous
- Mice
- Mice, Transgenic
- Models, Molecular
- Papio
- Phlebotomy
- Polymerase Chain Reaction
- RNA, Messenger -- analysis
- Small Molecule Libraries -- administration & dosage
- beta-Globins -- deficiency
- beta-Thalassemia -- drug therapy
- gamma-Globins -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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