Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.

Boosalis, Michael S

Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo. [electronic resource] - Blood cells, molecules & diseases Aug 2011 - 107-16 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1096-0961

10.1016/j.bcmd.2011.04.008 doi


Administration, Oral
Anemia--drug therapy
Animals
Biological Products--administration & dosage
Cells, Cultured
Drug Design
Erythroid Precursor Cells--cytology
Fetal Hemoglobin--biosynthesis
Gene Expression
Humans
Injections, Intravenous
Mice
Mice, Transgenic
Models, Molecular
Papio
Phlebotomy
Polymerase Chain Reaction
RNA, Messenger--analysis
Small Molecule Libraries--administration & dosage
beta-Globins--deficiency
beta-Thalassemia--drug therapy
gamma-Globins--biosynthesis