The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. [electronic resource]
Producer: 20110912Description: 947-51 p. digitalISSN:- 1521-009X
- Animals
- Antithyroid Agents -- pharmacokinetics
- Aryl Hydrocarbon Hydroxylases -- genetics
- Cytochrome P-450 CYP2A6
- Cytochrome P450 Family 2
- Liver -- drug effects
- Metabolic Clearance Rate
- Methimazole -- pharmacokinetics
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NADPH-Ferrihemoprotein Reductase -- genetics
- Olfactory Mucosa -- drug effects
- Organ Specificity
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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