The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5.
Xie, Fang
The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Jun 2011 - 947-51 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1521-009X
10.1124/dmd.110.037895 doi
Animals
Antithyroid Agents--pharmacokinetics
Aryl Hydrocarbon Hydroxylases--genetics
Cytochrome P-450 CYP2A6
Cytochrome P450 Family 2
Liver--drug effects
Metabolic Clearance Rate
Methimazole--pharmacokinetics
Mice
Mice, Inbred C57BL
Mice, Knockout
NADPH-Ferrihemoprotein Reductase--genetics
Olfactory Mucosa--drug effects
Organ Specificity
The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Jun 2011 - 947-51 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1521-009X
10.1124/dmd.110.037895 doi
Animals
Antithyroid Agents--pharmacokinetics
Aryl Hydrocarbon Hydroxylases--genetics
Cytochrome P-450 CYP2A6
Cytochrome P450 Family 2
Liver--drug effects
Metabolic Clearance Rate
Methimazole--pharmacokinetics
Mice
Mice, Inbred C57BL
Mice, Knockout
NADPH-Ferrihemoprotein Reductase--genetics
Olfactory Mucosa--drug effects
Organ Specificity