A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. [electronic resource]
Producer: 20111227Description: 273-88 p. digitalISSN:- 1942-0870
- Animals
- Antibodies, Bispecific -- immunology
- Antibodies, Monoclonal -- immunology
- Antibody Affinity -- immunology
- Antibody Specificity -- immunology
- Blotting, Western
- CHO Cells
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cricetinae
- Cricetulus
- Dose-Response Relationship, Drug
- ErbB Receptors -- immunology
- Humans
- Immunoglobulin G -- immunology
- Mice
- Mice, Nude
- Mice, SCID
- Neoplasms -- drug therapy
- Phosphorylation -- drug effects
- Receptor, IGF Type 1 -- immunology
- Signal Transduction -- drug effects
- Single-Chain Antibodies -- immunology
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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