A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity.
Dong, Jianying
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. [electronic resource] - mAbs - 273-88 p. digital
Publication Type: Journal Article
1942-0870
10.4161/mabs.3.3.15188 doi
Animals
Antibodies, Bispecific--immunology
Antibodies, Monoclonal--immunology
Antibody Affinity--immunology
Antibody Specificity--immunology
Blotting, Western
CHO Cells
Cell Line, Tumor
Cell Survival--drug effects
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
ErbB Receptors--immunology
Humans
Immunoglobulin G--immunology
Mice
Mice, Nude
Mice, SCID
Neoplasms--drug therapy
Phosphorylation--drug effects
Receptor, IGF Type 1--immunology
Signal Transduction--drug effects
Single-Chain Antibodies--immunology
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. [electronic resource] - mAbs - 273-88 p. digital
Publication Type: Journal Article
1942-0870
10.4161/mabs.3.3.15188 doi
Animals
Antibodies, Bispecific--immunology
Antibodies, Monoclonal--immunology
Antibody Affinity--immunology
Antibody Specificity--immunology
Blotting, Western
CHO Cells
Cell Line, Tumor
Cell Survival--drug effects
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
ErbB Receptors--immunology
Humans
Immunoglobulin G--immunology
Mice
Mice, Nude
Mice, SCID
Neoplasms--drug therapy
Phosphorylation--drug effects
Receptor, IGF Type 1--immunology
Signal Transduction--drug effects
Single-Chain Antibodies--immunology
Tumor Burden--drug effects
Xenograft Model Antitumor Assays