Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. [electronic resource]
Producer: 20110401Description: 1693-703 p. digitalISSN:- 1529-2401
- Aging -- genetics
- Animals
- Calcium -- metabolism
- Calcium Channels, L-Type -- metabolism
- Calcium Signaling
- Cells, Cultured
- Electrophysiology
- Gene Knockdown Techniques
- Genetic Vectors
- Hippocampus -- metabolism
- Homeostasis -- drug effects
- Immunohistochemistry
- Male
- Membrane Potentials -- drug effects
- Microinjections
- Patch-Clamp Techniques
- Polymerase Chain Reaction
- Pyramidal Cells -- metabolism
- Rats
- Rats, Inbred F344
- Ryanodine Receptor Calcium Release Channel -- metabolism
- Sirolimus -- pharmacology
- Tacrolimus Binding Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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