Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Gant, John C

Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Feb 2011 - 1693-703 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1529-2401

10.1523/JNEUROSCI.4805-10.2011 doi


Aging--genetics
Animals
Calcium--metabolism
Calcium Channels, L-Type--metabolism
Calcium Signaling
Cells, Cultured
Electrophysiology
Gene Knockdown Techniques
Genetic Vectors
Hippocampus--metabolism
Homeostasis--drug effects
Immunohistochemistry
Male
Membrane Potentials--drug effects
Microinjections
Patch-Clamp Techniques
Polymerase Chain Reaction
Pyramidal Cells--metabolism
Rats
Rats, Inbred F344
Ryanodine Receptor Calcium Release Channel--metabolism
Sirolimus--pharmacology
Tacrolimus Binding Proteins--genetics