The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. [electronic resource]
Producer: 20110316Description: 111-8 p. digitalISSN:- 1531-8249
- Aged
- Antiparkinson Agents -- pharmacokinetics
- Biological Availability
- Catechol O-Methyltransferase -- genetics
- Catechol O-Methyltransferase Inhibitors
- Catechols -- pharmacokinetics
- Cross-Over Studies
- Double-Blind Method
- Enzyme Inhibitors -- therapeutic use
- Female
- Genotype
- Humans
- Levodopa -- metabolism
- Male
- Methionine -- genetics
- Middle Aged
- Nitriles -- pharmacokinetics
- Parkinson Disease -- drug therapy
- Pharmacogenetics
- Polymorphism, Genetic
- Valine -- genetics
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Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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