The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial.
Corvol, Jean-Christophe
The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. [electronic resource] - Annals of neurology Jan 2011 - 111-8 p. digital
Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1531-8249
10.1002/ana.22155 doi
Aged
Antiparkinson Agents--pharmacokinetics
Biological Availability
Catechol O-Methyltransferase--genetics
Catechol O-Methyltransferase Inhibitors
Catechols--pharmacokinetics
Cross-Over Studies
Double-Blind Method
Enzyme Inhibitors--therapeutic use
Female
Genotype
Humans
Levodopa--metabolism
Male
Methionine--genetics
Middle Aged
Nitriles--pharmacokinetics
Parkinson Disease--drug therapy
Pharmacogenetics
Polymorphism, Genetic
Valine--genetics
The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. [electronic resource] - Annals of neurology Jan 2011 - 111-8 p. digital
Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
1531-8249
10.1002/ana.22155 doi
Aged
Antiparkinson Agents--pharmacokinetics
Biological Availability
Catechol O-Methyltransferase--genetics
Catechol O-Methyltransferase Inhibitors
Catechols--pharmacokinetics
Cross-Over Studies
Double-Blind Method
Enzyme Inhibitors--therapeutic use
Female
Genotype
Humans
Levodopa--metabolism
Male
Methionine--genetics
Middle Aged
Nitriles--pharmacokinetics
Parkinson Disease--drug therapy
Pharmacogenetics
Polymorphism, Genetic
Valine--genetics