New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases. [electronic resource]
Producer: 20110307Description: 534-47 p. digitalISSN:- 1520-4804
- 17-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors
- Administration, Oral
- Animals
- Biological Availability
- Cell Line, Tumor
- Cell Membrane Permeability
- Cell-Free System
- Estrogen Receptor alpha -- metabolism
- Estrogen Receptor beta -- metabolism
- Estrogens -- physiology
- Female
- Humans
- Liver -- metabolism
- Male
- Microsomes -- drug effects
- Molecular Mimicry
- Naphthols -- chemical synthesis
- Phenols -- chemical synthesis
- Placenta -- enzymology
- Pregnancy
- Rats
- Rats, Sprague-Dawley
- Rats, Wistar
- Recombinant Proteins -- antagonists & inhibitors
- Steroids -- chemistry
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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